Cancer Biology

Description

This module focuses on the mechanism of cancer generation and progression and on the range of treatment options. Starting with a background integrating genetic, cellular, and molecular aspects, it covers recent cancer research leading to a general conceptual framework for the development of this disease. The module also provides insights and illustrations from specific cancer types and concludes with a variety of established and emerging treatments. The overall aim of this module is to provide a strong background for careers related to basic cancer research, experimental medicine, and drug discovery. Indicative lecture list: Properties of transformed cells Cell division and cell cycle Cellular senescence and immortalisation Oncogenic subversion and signal transduction Tumour suppressor genes Angiogenesis in cancer Cancer metabolism Cancer stem Cells The role of metastasis in cancer Intratumour heterogeneity, tumour evolution and clinical implications Epithelial cancer: breast cancer Leukaemia’s Novel therapeutics Targeted cancer therapy Exploiting DNA damage response in cancer therapy